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Some antidepressants known as MAOIs work by enhancing the brain's neurotransmitter receptor ability. com, as a result of higher risk of kidney stones, patients with kidney stone history or taking high dose vitamin C or calcium supplements should not use Topamax. Robert Baker, global development leader at Lilly, manufactures from the drug, states it's important for persons with chronic musculoskeletal pain have different treatment choices available because effects in medications could be individualized. Serotonin-norepinephrine reuptake inhibitors (SNRIs) are newer than both tricyclics and SSRIs, and focus on both norepinephrine and serotonin. The proven fact that there might be a new breakthrough using this type of very versatile drug within the treatment of lower back pain is exciting for those that suffer through the chronic disorder. 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